Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells.

  • Ward M
  • Rego A
  • Frenguelli B
 et al. 
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Abstract

The relationship between changes in mitochondrial membrane potential (Deltapsi(m)) and the failure of cytoplasmic Ca(2+) homeostasis, delayed Ca(2+)deregulation (DCD), is investigated for cultured rat cerebellar granule cells exposed to glutamate. To interpret the single-cell fluorescence response of cells loaded with tetramethylrhodamine methyl ester (TMRM(+)) or rhodamine-123, we devised and validated a mathematical simulation with well characterized effectors of Deltapsi(m) and plasma membrane potential (Deltapsi(P)). Glutamate usually caused an immediate decrease in Deltapsi(m) of

Author-supplied keywords

  • Action Potentials
  • Action Potentials: drug effects
  • Adenosine Triphosphate
  • Adenosine Triphosphate: metabolism
  • Animals
  • Anti-Bacterial Agents
  • Anti-Bacterial Agents: pharmacology
  • Antimycin A
  • Antimycin A: pharmacology
  • Calcium
  • Calcium: metabolism
  • Cells, Cultured
  • Cerebellum
  • Cerebellum: cytology
  • Cerebellum: drug effects
  • Cerebellum: metabolism
  • Cytoplasmic Granules
  • Enzyme Inhibitors
  • Enzyme Inhibitors: pharmacology
  • Fluorescent Dyes
  • Glutamic Acid
  • Glutamic Acid: metabolism
  • Glutamic Acid: pharmacology
  • Intracellular Membranes
  • Intracellular Membranes: metabolism
  • Membrane Potentials
  • Membrane Potentials: drug effects
  • Mitochondria
  • Mitochondria: metabolism
  • Potassium Chloride
  • Potassium Chloride: metabolism
  • Potassium Chloride: pharmacology
  • Rats
  • Rats, Wistar
  • Receptors, Glutamate
  • Receptors, Glutamate: metabolism
  • Rhodamines
  • Uncoupling Agents
  • Uncoupling Agents: pharmacology

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Authors

  • M W Ward

  • a C Rego

  • B G Frenguelli

  • D G Nicholls

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