Mitochondrial protein import and human health and disease

  • MacKenzie J
  • Payne R
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The targeting and assembly of nuclear-encoded mitochondrial proteins are essential processes because the energy supply of humans is dependent upon the proper functioning of mitochondria. Defective import of mitochondrial proteins can arise from mutations in the targeting signals within precursor proteins, from mutations that disrupt the proper functioning of the import machinery, or from deficiencies in the chaperones involved in the proper folding and assembly of proteins once they are imported. Defects in these steps of import have been shown to lead to oxidative stress, neurodegenerative diseases, and metabolic disorders. In addition, protein import into mitochondria has been found to be a dynamically regulated process that varies in response to conditions such as oxidative stress, aging, drug treatment, and exercise. This review focuses on how mitochondrial protein import affects human health and disease

Author-supplied keywords

  • Affect
  • Aging
  • Animals
  • Disease
  • Exercise
  • Health
  • Humans
  • Lead
  • Liver Diseases,Alcoholic
  • Metabolic Diseases
  • Mitochondria
  • Mitochondrial Diseases
  • Mitochondrial Proteins
  • Mutation
  • Neurodegenerative Diseases
  • New York
  • Oxidative Stress
  • Protein Folding
  • Protein Transport
  • Proteins
  • Research
  • Science
  • Universities
  • chemistry
  • deficiency
  • genetics
  • metabolism

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PMID: 17300922


  • J A MacKenzie

  • R M Payne

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free