A Model for all Genomes: The Role of Transcription Factories

  • Cook P
  • 214


    Mendeley users who have this article in their library.
  • 145


    Citations of this article.


A model for all genomes involving one major architectural motif is presented: DNA or chromatin loops are tethered to "factories" through the transcription machinery-a polymerase (active or inactive) or its transcription factors (activators or repressors). These loops appear and disappear as polymerases initiate and terminate (and as factors bind and dissociate), so the structure is ever-changing and self-organizing. This model is parsimonious, detailed (and so easily tested), and incorporates elements found in various other models. © 2009 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • RNA polymerase
  • chromatin loop
  • chromosome
  • transcription factor
  • transcription factory

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Peter R. Cook

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free