Modeling of drug release from swellable polymers

  • Brazel C
  • Peppas N
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Abstract

The water swelling and drug diffusion from initially hydrophilic, glassy polymer matrices were modeled using concentration-dependent diffusion equations for water and drug. The transport equation for water incorporated a relaxation-dependent mechanism. These equations were solved with an appropriate boundary condition incorporating a relaxation-dependent Deborah number. Experimental results from drug release from PVA and PHEMA samples were used to determine the validity of the model.

Author-supplied keywords

  • Drug release
  • Poly(2- hydroxyethyl methacrylate)
  • Poly(vinyl alcohol)
  • Relaxation
  • Swellable systems

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