Modeling of drug release from swellable polymers

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Abstract

The water swelling and drug diffusion from initially hydrophilic, glassy polymer matrices were modeled using concentration-dependent diffusion equations for water and drug. The transport equation for water incorporated a relaxation-dependent mechanism. These equations were solved with an appropriate boundary condition incorporating a relaxation-dependent Deborah number. Experimental results from drug release from PVA and PHEMA samples were used to determine the validity of the model.

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Brazel, C. S., & Peppas, N. A. (2000). Modeling of drug release from swellable polymers. European Journal of Pharmaceutics and Biopharmaceutics, 49(1), 47–58. https://doi.org/10.1016/S0939-6411(99)00058-2

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