Modelo de obesidade induzida por dieta hiperlipídica e associada à resistência à ação da insulina e intolerância à glicose

  • White P
  • Cercato L
  • Araújo J
 et al. 
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Abstract

OBJECTIVE: Validate a model of high-fat diet-induced obesity, of low cost, easy reproducibility, that could express characteristics observed in human, and would enable subsequent therapy proposals. MATERIALS AND METHODS: Sixteen Swiss mice received a standard diet (DP) or high-fat diet (DH) for 10 weeks. RESULTS: Although the DP group had greater water (p < 0.01) and feed (p < 0.001) consumption, the DH group had greater body weight (p < 0.5) and adipose tissue gain (p < 0.001), favoring higher adiposity index (p < 0.001), glucose (p < 0.01), and area under the curve in the insulin (p < 0.001) and glucose (p < 0.01) tolerance tests. CONCLUSION: A high-fat diet-induced obesity model has been validated, which was also associated with insulin resistance and glucose intolerance after a period of 10 weeks.

Author-supplied keywords

  • correspondência para
  • glucose intolerance
  • high-fat diet
  • insulin resistance
  • mice
  • obesity

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Authors

  • Pollyanna A. S. White

  • Luana M. Cercato

  • Jéssica M. D. Araújo

  • Lucas A. Souza

  • Andréa F. Soares

  • Ana Paula O. Barbosa

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