Modulation of the intramedullary pressure responses by calcium dobesilate in a rabbit knee model of osteoarthritis

  • Miles J
  • Wenck A
  • Fricker C
 et al. 
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Abstract

The presence of bone marrow edema in patients with osteoarthritis is associated with pain and disease progression. Management of bone edema with the synthetic prostacyclin iloprost may be complicated by side effects. Calcium dobesilate, a treatment for chronic venous disease, shares some pharmacological actions with iloprost but appears to be better tolerated. Anecdotal reports have suggested that calcium dobesilate may be useful for medical management of osteoarthritis, possibly by reducing bone marrow edema, and this study was performed to investigate possible benefits of treatment.

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Authors

  • James MilesKobenhavns Universitet Sundhedsvidenskabelige Fakultet

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  • Asger Wenck

  • Christian Fricker

  • Eiliv L. Svalastoga

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