Molar efficiency: A useful metric to gauge relative reaction efficiency in discovery medicinal chemistry

  • McGonagle F
  • Sneddon H
  • Jamieson C
 et al. 
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Abstract

The concept of molar efficiency is introduced as a new metric to enable
assessment of reaction efficiency in discovery medicinal chemistry.
Calculations from molar units enable cross-comparison of the broad range
of transformations employed in discovery-phase medicinal chemistry
research and is proposed to facilitate identification of more
sustainable synthetic transformations.

Author-supplied keywords

  • Discovery medicinal chemistry
  • Metrics
  • reaction efficiency

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Authors

  • Fiona I. McGonagle

  • Helen F. Sneddon

  • Craig Jamieson

  • Allan J B Watson

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