Molecular Alterations Associated with Breast Cancer Mortality

  • L.M. V
  • K. M
  • J.L. C
 et al. 
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Background: Breast cancer is a heterogeneous disease and patients with similar pathologies and treatments may have different clinical outcomes. Identification of molecular alterations associated with disease outcome may improve risk assessment and treatments for aggressive breast cancer. Methods: Allelic imbalance (AI) data was generated for 122 invasive breast tumors with known clinical outcome. Levels and patterns of AI were compared between patients who died of disease (DOD) and those with ≥5 years disease-free survival (DFS) using Student t-test and chi-square analysis with a significance value of P5-years post-diagnosis) mortality but not with death from disease within five years, suggesting that patients with short- and long-term mortality may have distinct genetic diseases. © 2012 Voeghtly et al.

Author-supplied keywords

  • Allelic Imbalance
  • Breast Neoplasms
  • Disease-Free Survival
  • Female
  • Humans
  • adult
  • allelic imbalance
  • article
  • breast cancer
  • cancer mortality
  • cancer prognosis
  • chromosome 13q
  • chromosome 16q
  • chromosome 17p
  • chromosome 22q
  • chromosome 7q
  • chromosome 8p
  • controlled study
  • disease free survival
  • female
  • genetic association
  • genetics
  • genomic instability
  • human
  • human tissue
  • major clinical study
  • mortality
  • pathology

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  • Voeghtly L.M.

  • Mamula K.

  • Campbell J.L.

  • Shriver C.D.

  • Ellsworth R.E.

  • Laura M Voeghtly

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