Molecular arrangements and interconnected bilayer formation induced by alcohol or polyalcohol in phospholipid vesicles

  • Manca M
  • Castangia I
  • Matricardi P
 et al. 
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Abstract

A self-assembled hybrid phospholipid vesicular system containing various penetration enhancers - ethanol, Transcutol and propylenglycol - was prepared and characterized. The effects of the different alcohol or polyalcohols structure and their concentration on the features of the assembled vesicles were evaluated using a combination of different techniques, including cryo-transmission electron microscopy, laser light scattering, differential scanning calorimetry, small- and wide-angle X-ray scattering and rheological analysis. These techniques allow explaining the structural rearrangements of the bilayer assembly due to the alcohol or polyalcohol addition. X-ray scattering studies showed that such addition at the highest concentration (20%) allowed structure modification to oligolamellar vesicles and a bilayer transition to interdigitated phase. Rheological studies confirmed the importance of alcohol or polyalcohol in the structuring dispersions probably due to a partial tilting of phosphatidylcholine acyl chains forming interdigitated and interconnected bilayer vesicles. © 2014 Elsevier B.V.

Author-supplied keywords

  • (Poly)alcohols
  • Cryo-TEM
  • DSC
  • Liposomes
  • Penetration Enhancer containing Vesicle (PEVs)
  • Rheology
  • SAXS

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