Molecular cloning and functional expression of a serotonin receptor from Caenorhabditis elegans

  • Olde B
  • McCombie W
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Abstract

A cDNA encoding a serotonin receptor has been isolated from a Caenorhabditis elegans mixed stage cDNA library. The nematode serotonin receptor, designated 5HT-Ce, was permanently expressed in murine Ltk-cells, where it mediates adenylate cyclase attenuation. Sequence analysis and the pharmacological profiles demonstrate its relatedness not only to Drosophila and Lymnae 5HT receptors but also to mammalian 5HT1a receptors. The 5HT-Ce-gene does not map close to the position of any known serotonergic mutations

Author-supplied keywords

  • Adenylate Cyclase
  • Animals
  • Base Sequence
  • CAENORHABDITIS-ELEGANS
  • CDNA
  • CLONING
  • Caenorhabditis elegans
  • Cloning,Molecular
  • Cos Cells
  • DNA
  • DNA,Complementary
  • Drosophila
  • EXPRESSION
  • Gene expression
  • MOLECULAR-CLONING
  • Molecular Sequence Data
  • Mutation
  • RECEPTOR
  • Receptors
  • Receptors,Serotonin
  • Research
  • SEQUENCE
  • Sequence Homology,Amino Acid
  • Serotonin
  • analysis
  • antagonists & inhibitors
  • chromosome mapping
  • enzymology
  • genetics
  • metabolism
  • pharmacology
  • physiology

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  • PMID: 9061615

Authors

  • B Olde

  • W R McCombie

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