Molecular imaging with Pittsburgh compound B confirmed at autopsy: A case report

  • Bacskai B
  • Frosch M
  • Freeman S
 et al. 
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OBJECTIVE: To determine the correspondence between uptake of Pittsburgh Compound B (PiB) in life and measures of beta-amyloid (Abeta) in postmortem tissue analysis. Patient A 76-year-old man with a clinical diagnosis of dementia with Lewy bodies underwent fluorodeoxyglucose (18)F and PiB positron emission tomographic brain scans. Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan.

RESULTS: Autopsy confirmed the clinical diagnosis; in addition, there was severe cerebral amyloid angiopathy and only moderate numbers of parenchymal Abeta plaques. Biochemical measures revealed a positive correlation between Abeta levels and regional PiB binding.

CONCLUSION: This report confirms that PiB detects Abeta in the living patient and demonstrates that amyloid deposited as cerebral amyloid angiopathy can be the dominant source of signal.

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  • Matthew P. Frosch

  • Stefanie H. Freeman

  • Scott B. Raymond

  • Jean C. Augustinack

  • Keith A. Johnson

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