Molecular mechanisms of the cardiovascular protective effects of polyphenols

  • Andriantsitohaina R
  • Auger C
  • Chataigneau T
 et al. 
  • 107

    Readers

    Mendeley users who have this article in their library.
  • 82

    Citations

    Citations of this article.

Abstract

Epidemiological studies have reported a greater reduction in cardiovascular risk and metabolic disorders associated with diets rich in polyphenols. The antioxidant effects of polyphenols are attributed to the regulation of redox enzymes by reducing reactive oxygen species production from mitochondria, NADPH oxidases and uncoupled endothelial NO synthase in addition to also up-regulating multiple antioxidant enzymes. Although data supporting the effects of polyphenols in reducing oxidative stress are promising, several studies have suggested additional mechanisms in the health benefits of polyphenols. Polyphenols from red wine increase endothelial NO production leading to endothelium-dependent relaxation in conditions such as hypertension, stroke or the metabolic syndrome. Numerous molecules contained in fruits and vegetables can activate sirtuins to increase lifespan and silence metabolic and physiological disturbances associated with endothelial NO dysfunction. Although intracellular pathways involved in the endothelial effects of polyphenols are partially described, the molecular targets of these polyphenols are not completely elucidated. We review the novel aspects of polyphenols on several targets that could trigger the health benefits of polyphenols in conditions such as metabolic and cardiovascular disturbances.

Author-supplied keywords

  • Antioxidants
  • Cardiovascular system
  • Endothelium
  • Free radicals
  • Nitric oxide
  • Polyphenols

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Ramaroson Andriantsitohaina

  • Cyril Auger

  • Thierry Chataigneau

  • Nelly Étienne-Selloum

  • Huige Li

  • M. Carmen Martínez

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free