Molecular mechanisms underlying the memory-enhancing effects of estradiol

  • Frick K
  • Readers

    Mendeley users who have this article in their library.
  • Citations

    Citations of this article.


This article is part of a Special Issue "Estradiol and cognition".Since the publication of the 1998 special issue of Hormones and Behavior on estrogens and cognition, substantial progress has been made towards understanding the molecular mechanisms through which 17β-estradiol (E2) regulates hippocampal plasticity and memory. Recent research has demonstrated that rapid effects of E2on hippocampal cell signaling, epigenetic processes, and local protein synthesis are necessary for E2to facilitate the consolidation of object recognition and spatial memories in ovariectomized female rodents. These effects appear to be mediated by non-classical actions of the intracellular estrogen receptors ERα and ERβ, and possibly by membrane-bound ERs such as the G-protein-coupled estrogen receptor (GPER). New findings also suggest a key role of hippocampally-synthesized E2in regulating hippocampal memory formation. The present review discusses these findings in detail and suggests avenues for future study.

Author-supplied keywords

  • Cell signaling
  • DNA methylation
  • ERK
  • Epigenetic
  • Estrogen
  • Estrogen receptor
  • GPER
  • Hippocampus
  • Histone acetylation
  • MTOR

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Karyn M. Frick

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free