Molecular targets of natural health products in arthritis.

  • Khalifé S
  • Zafarullah M
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Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) consume 'natural health products' (NHPs) whose therapeutic efficacy, toxicity and mechanisms of action are poorly understood. In a previous issue of Arthritis Research and Therapy, Haqqi and colleagues characterized IL-1-activated mitogen-activated protein kinase kinase 3 (MKK3) and p38-mitogen-activated protein kinase (MAPK) isoforms in human OA chondrocytes. The cartilageprotective mechanisms of pomegranate extract involve diminishing MKK3-activated p38α, JNK, NF-κB and Runx2 pathways, which regulate inflammatory proteins and cartilage-destroying proteases. Epigallocatechin- 3-gallate, resveratrol, curcumin and other NHP active ingredients suppress multiple inflammatory and catabolic molecular mediators of arthritis. Non-toxicity, reduced severity and incidence of arthritis in animal models warrant testing NHP active ingredients for preventing human OA and RA.

Author-supplied keywords

  • Animals
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents: pharmacology
  • Antioxidants
  • Antioxidants: pharmacology
  • Arthritis
  • Arthritis: drug therapy
  • Complementary Therapies
  • Complementary Therapies: methods
  • Health Food
  • Humans

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  • Sarah Khalifé

  • Muhammad Zafarullah

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