Molecularly imprinted monodisperse microspheres for competitive radioassay

  • Ye L
  • Cormack P
  • Mosbach K
  • 65


    Mendeley users who have this article in their library.
  • 239


    Citations of this article.


In the present study, molecularly imprinted affinity sorbents against theophylline and 17[small beta]-estradiol are synthesised via precipitation polymerisation, a synthetic method that yields monodisperse, spherical polymer particles in the micron-scale range, quickly, cleanly and in good yield. The specific binding sites that are created during the imprinting process are analysed via radioligand binding analysis. The molecularly imprinted microspheres are highly specific and have higher load capacities compared to the 'classical' particles obtained by grinding the imprinted monolith. The successful imprinting against model compounds with very different hydrophobicities demonstrates the generality of the current simple approach.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Lei YeLunds Universitet

  • Peter A.G. Cormack

  • Klaus Mosbach

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free