Monotherapy Versus Combination Therapy

  • S.M. P
  • L.D. S
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Abstract

In summary, several treatment options are available for patients with these common infectious diseases (Table 2). When empiric treatment is needed, combination therapy is often advised, with subsequent modification of antibiotic therapy once further information becomes available. In all cases, the potential risk/benefit of combination therapy versus monotherapy must be considered. If hospitalized patients are treated with parenteral antibiotics, they should be switched to an oral regimen once clinical improvement occurs, if appropriate. Regimens should be simple and cost-effective, with consideration given to the diagnosis, clinical response, patient compliance, and ease of administration. The topic of combination therapy versus monotherapy continues to evolve. © 2006 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • Aggregatibacter actinomycetemcomitans
  • Cardiobacterium hominis
  • Eikenella corrodens
  • Enterococcus faecalis
  • Haemophilus influenzae
  • Haemophilus parainfluenzae
  • Kingella kingae
  • Staphylococcus aureus
  • Streptococcus pneumoniae
  • Streptococcus pyogenes
  • alpha hemolytic Streptococcus
  • aminoglycoside antibiotic agent
  • amoxicillin plus clavulanic acid
  • antibiotic agent
  • antibiotic therapy
  • azithromycin
  • aztreonam
  • bacterial infection
  • beta lactam
  • cefalexin
  • cefazolin
  • ceftazidime
  • cefuroxime axetil
  • cellulitis
  • cephalosporin
  • ciprofloxacin
  • clarithromycin
  • clindamycin
  • clinical trial
  • combination chemotherapy
  • cotrimoxazole
  • daptomycin
  • diarrhea
  • dicloxacillin
  • diverticulitis
  • drug hypersensitivity
  • endocarditis
  • erythromycin
  • febrile neutropenia
  • gatifloxacin
  • gentamicin
  • human
  • levofloxacin
  • linezolid
  • liver toxicity
  • meningitis
  • monotherapy
  • moxifloxacin
  • nafcillin
  • nephrotoxicity
  • osteomyelitis
  • ototoxicity
  • oxacillin
  • penicillin G
  • penicillin allergy
  • piperacillin plus tazobactam
  • pneumonia
  • priority journal
  • quinoline derived antiinfective agent
  • review
  • thrombocytopenia
  • unindexed drug
  • vancomycin

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Authors

  • Patel S.M.

  • Saravolatz L.D.

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