In summary, several treatment options are available for patients with these common infectious diseases (Table 2). When empiric treatment is needed, combination therapy is often advised, with subsequent modification of antibiotic therapy once further information becomes available. In all cases, the potential risk/benefit of combination therapy versus monotherapy must be considered. If hospitalized patients are treated with parenteral antibiotics, they should be switched to an oral regimen once clinical improvement occurs, if appropriate. Regimens should be simple and cost-effective, with consideration given to the diagnosis, clinical response, patient compliance, and ease of administration. The topic of combination therapy versus monotherapy continues to evolve. © 2006 Elsevier Inc. All rights reserved.
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