Morbidity and prognostic factors in chronic chagasic cardiopathy.

  • Rocha M
  • Nunes M
  • Ribeiro A
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Chagas disease is a pleomorphic clinical entity that has several unique features. The aim of this study is to summarise some of the recent contributions from our research group to knowledge of the morbidity and prognostic factors in Chagas heart disease. A retrospective study suggested that ischaemic stroke associated with left ventricular (LV) apical thrombi is the first clinical manifestation of Chagas disease observed in a large proportion of patients. LV function and left atrial volume (LAV) are independent risk factors for ischaemic cerebrovascular events during follow-up of Chagas heart disease patients. Pulmonary congestion in Chagas-related dilated cardiomyopathy is common but usually mild. Although early right ventricular (RV) involvement has been described, we have shown by Doppler echocardiography that RV dysfunction is evident almost exclusively when it is associated with left ventricle dilatation and functional impairment. In addition, RV dysfunction is a powerful predictor of survival in patients with heart failure secondary to Chagas disease. We have also demonstrated that LAV provides incremental prognostic information independent of clinical data and conventional echocardiographic parameters that predict survival.

Author-supplied keywords

  • Chagas Cardiomyopathy
  • Chronic Disease
  • Electrocardiography
  • Heart Failure
  • Humans
  • Prognosis
  • Ultrasonography
  • Ventricular Dysfunction
  • diagnostic imaging
  • mortality
  • physiopathology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Manoel Otavio C Rocha

  • Maria Carmo P Nunes

  • Antonio L Ribeiro

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free