MR elastography (MRE) is a phase contrast-based technique for spatially mapping the mechanical properties of tissue-like materials. While hyperpolarized noble gases such as helium-3 ((3)He) have proven to be an ideal contrast mechanism for imaging of the lung using conventional MR techniques, their applicability for lung MRE is unknown, due to the fact that gases do not support shear. In this study, we report on the application of MRE to an ex vivo porcine lung specimen inflated with a hyperpolarized noble gas. Unlike proton MRE, shear wave propagation is encoded into the gas entrapped within the alveolar spaces rather than the parenchyma itself. These data provide first evidence of the technical feasibility of MRE of the lung using hyperpolarized noble gases.
Mendeley saves you time finding and organizing research
Choose a citation style from the tabs below