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Journal article

mRDH bandage for surgery and trauma: data summary and comparative review.

Valeri C, Vournakis J...(+2 more)

The Journal of trauma, vol. 71, issue 2 Suppl 1 (2011) pp. S162-6

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Abstract

BACKGROUND: Bleeding often poses significant life-threatening situations to surgeons. After trauma, a one-third of civilian casualties and one-half of combat casualties die as a result of exsanguination. Recent advances have provided promising new hemostatic dressings that are applied directly to severely bleeding wounds in the pre-hospital period.

METHODS: The modified Rapid Deployment Hemostat (mRDH) trauma/surgery bandage, containing fully acetylated, diatom-derived, poly-N-acetyl-glucosamine fibers, has a unique multifactorial hemostatic action that incorporates vasoconstriction, erythrocyte agglutination, and platelet and RBC activation.

RESULTS: Animal studies have shown that the mRDH bandage quickly and completely stops both venous and arterial bleeding, even in the presence of a coagulopathy. A prospective study in humans is in accord with these findings.

CONCLUSION: The mRDH trauma/surgery bandage was able to increase survival of patients after high-grade liver trauma with an associated coagulopathy. Additional clinical studies support this result.

Author-supplied keywords

  • Acetylglucosamine
  • Acetylglucosamine: therapeutic use
  • Bandages
  • Hemorrhage
  • Hemorrhage: etiology
  • Hemorrhage: prevention & control
  • Hemostasis, Surgical
  • Humans
  • Wounds and Injuries
  • Wounds and Injuries: complications
  • Wounds and Injuries: therapy

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