J Trauma, vol. 71, issue 2 (2011) pp. S162-S166 Published by From the Naval Blood Research Laboratory, Inc. (C.R.V.), Boston, Massachusetts; and Marine Polymer Technologies, Inc. (J.N.V.), Burlington, Massachusetts.
Background: Bleeding often poses significant life-threatening situations to surgeons. After trauma, a one-third of civilian casualties and one-half of combat casualties die as a result of exsanguination. Recent advances have provided promising new hemostatic dressings that are applied directly to severely bleeding wounds in the pre-hospital period., Methods: The modified Rapid Deployment Hemostat (mRDH) trauma/surgery bandage, containing fully acetylated, diatom-derived, poly-N-acetyl-glucosamine fibers, has a unique multifactorial hemostatic action that incorporates vasoconstriction, erythrocyte agglutination, and platelet and RBC activation., Results: Animal studies have shown that the mRDH bandage quickly and completely stops both venous and arterial bleeding, even in the presence of a coagulopathy. A prospective study in humans is in accord with these findings., Conclusion: The mRDH trauma/surgery bandage was able to increase survival of patients after high-grade liver trauma with an associated coagulopathy. Additional clinical studies support this result., (C) 2011 Lippincott Williams & Wilkins, Inc.
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