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Journal article

Can MRI replace DMSA in the detection of renal parenchymal defects in children with urinary tract infections?

Kavanagh E, Ryan S, Awan A, McCourbrey S, O'Connor R, Donoghue V ...see all

Pediatric Radiology, vol. 35, issue 3 (2005) pp. 275-281

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BACKGROUND: Renal parenchymal defects may be a consequence of urinary tract infections (UTI) in childhood. MRI is a non-radiation imaging modality compared with DMSA scanning.

OBJECTIVE: To compare DMSA with MRI for the detection of renal parenchymal defects in children presenting for radiological investigation after a first UTI.

MATERIALS AND METHODS: Both DMSA and MRI were performed at the same appointment in 37 children (aged 4 months-13 years; mean 4.5 years) with a history of UTI. Both planar and SPECT DMSA were performed. MRI of the kidneys employed axial and coronal T1-, T2- and fat-saturated T1-weighted (T1-W) sequences. Some children had imaging after IV contrast medium.

RESULTS: The coronal fat-saturated T1-W sequence was the best sequence and it detected all the findings on MRI. MRI had a sensitivity of 77% and a specificity of 87% for the detection of a scarred kidney using DMSA as the gold standard. MRI diagnosed pyelonephritis in two children that had been interpreted as scarring on DMSA.

CONCLUSIONS: Renal MRI using a single, coronal, fat-saturated T1-W sequence is a rapid, accurate and minimally invasive technique for the detection of renal scarring that does not employ ionizing radiation.

Author-supplied keywords

  • Children
  • DMSA
  • Infection
  • Kidney
  • MRI
  • Scarring

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  • Eoin C. Kavanagh

  • Stephanie Ryan

  • Atif Awan

  • Siobhan McCourbrey

  • Rachel O'Connor

  • Veronica Donoghue

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