Mucosal immunity and nasal influenza vaccination

  • Rose M
  • Zielen S
  • Baumann U
  • 33


    Mendeley users who have this article in their library.
  • 46


    Citations of this article.


Influenza remains a threat to public health, with immunization being a suitable method of infection prevention and control. Our understanding of the immunological regulations at the mucosa, antigen processing and presentation, and B-cell activation has improved, enabling research and targeted induction of immune responses at the site of antigen delivery. Nasal influenza immunization has distinct features compared with intramuscular vaccines, providing protection at the pathogen's entry site, higher levels of mucosal antibodies, cross-protection and needle-free application. This review summarizes our knowledge about mucosal immunity and the experience from clinical trials on the impact and safety of nasal influenza vaccination.

Author-supplied keywords

  • children
  • mucosal immunization
  • nasal influenza vaccination

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Markus A. Rose

  • Stefan Zielen

  • Ulrich Baumann

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free