Multigenerational familial medullary thyroid cancer (FMTC): Evidence for FMTC phenocopies and association with papillary thyroid cancer

  • Fugazzola L
  • Cerutti N
  • Mannavola D
 et al. 
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Abstract

Occurrence in a familial setting is well established for medullary thyroid carcinoma (MTC) and has been more recently reported for papillary thyroid cancer (PTC). Germline mutations or rearrangements of the RET proto-oncogene are the genetic background of the majority of hereditary MTCs and of about 25-40% of PTCs.

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