Topological sensitivity analysis is performed for the piecewise constant Mumford-Shah functional. Topological and shape derivatives are combined in order to derive an algorithm for image segmentation with fully automatized initialization. Segmentation of 2D and 3D data is presented. Further, a generalized Mumford-Shah functional is proposed and numerically investigated for the segmentation of images modulated due to, e.g., coil sensitivities.
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