Multiple sclerosis as a generalized CNS disease - Comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS

  • Lindberg R
  • De Groot C
  • Certa U
 et al. 
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We used microarrays to compare the gene expression profile in active lesions and donor-matched normal appearing white matter (NAWM) from brain autopsy samples of patients with secondary progressive multiple sclerosis (MS) with that from controls who died from non-neurological diseases. The 123 genes in lesions, and 47 genes in NAWM MS were differentially expressed. Lesions distinguished from NAWM MS by a higher expression of genes related to immunoglobulin synthesis and neuroglial differentiation, while cellular immune response elements were equally dysregulated in both tissue compartments. Current results provide molecular evidence of a continuum of dysfunctional homeostasis and inflammatory changes between lesions and NAWM MS , and support the concept of MS pathogenesis being a generalised process that involves the entire CNS. © 2004 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Differential gene expression
  • Lesion
  • Microarray
  • Multiple sclerosis
  • Normal appearing white matter

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  • R.L.P. Lindberg

  • C.J.A. De Groot

  • U. Certa

  • R. Ravid

  • F. Hoffmann

  • L. Kappos

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