Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications

  • Wess J
  • 11


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Muscarinic acetylcholine receptors (mAChRs; M1-M5) play key roles in regulating the activity of many important functions of the central and peripheral nervous system. Because of the lack of ligands endowed with a high degree of receptor subtype selectivity and the fact that most tissues or cell types express two or more mAChR subtypes, identification of the physiological and pathophysiological roles of the individual mAChR subtypes has proven a difficult task. To circumvent these difficulties, several laboratories recently employed gene-targeting techniques to generate mutant mouse strains deficient in each of the five mAChR subtypes. Phenotyping studies showed that each mutant mouse line displayed characteristic physiological, pharmacological, behavioral, biochemical, or neurochemical deficits. The novel insights gained from these studies should prove instrumental for the development of novel classes of muscarinic drugs.

Author-supplied keywords

  • Animals
  • Electrophysiology
  • Learning/physiology
  • Mice
  • Mice, Knockout
  • Models, Animal
  • Muscarinic Agonists/pharmacology
  • Phenotype
  • Receptors, Muscarinic/*genetics/*physiology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • J Wess

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free