Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability.

  • Brundage L
  • Avery L
  • Katz A
 et al. 
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Abstract

We find that C. elegans egl-30 encodes a heterotrimeric G protein a subunit more than 80% identical to mammalian Gqalpha family proteins, and which can function as a Gqalpha subunit in COS-7 cells. We have identified new egl-30 alleles in a selection for genes involved in the C. elegans acetylcholine response. Two egl-30 alleles specify premature termination of Gqalpha and are essentially lethal in homozygotes. Animals homozygous for six other egl-30 alleles are viable and fertile, but exhibit delayed egg laying and leave flattened tracks. Overexpression of the wild-type egl-30 gene produces the opposite behavior. Analysis of these mutants suggest that their phenotypes reflect defects in the muscle or neuromuscular junction.

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Authors

  • L Brundage

  • L Avery

  • A Katz

  • U J Kim

  • J E Mendel

  • P W Sternberg

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