Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure.

  • Wallhaus T
  • Taylor M
  • DeGrado T
 et al. 
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BACKGROUND: Use of beta-adrenoreceptor blockade in the treatment of heart failure has been associated with a reduction in myocardial oxygen consumption and an improvement in myocardial energy efficiency. One potential mechanism for this beneficial effect is a shift in myocardial substrate use from increased free fatty acid (FFA) oxidation to increased glucose oxidation. METHODS AND RESULTS: We studied the effect of carvedilol therapy on myocardial FFA and glucose use in 9 patients with stable New York Heart Association functional class III ischemic cardiomyopathy (left ventricular ejection fraction

Author-supplied keywords

  • -adrenorecep-
  • can result in a
  • chronic heart failure
  • dramatic improvement in left
  • failure
  • fatty acids ⅲ glucose
  • ignificant evidence has demonstrated
  • setting of stable
  • that
  • tor blockade in the
  • ventricular
  • ⅲ metabolism ⅲ heart

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  • T R Wallhaus

  • M Taylor

  • T R DeGrado

  • D C Russell

  • P Stanko

  • R J Nickles

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