Abstract
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease. © 2011 Elsevier Ltd. All rights reserved.
Author supplied keywords
Cite
CITATION STYLE
APA
Gage, J. L., Onrust, R., Johnston, D., Osnowski, A., MacDonald, W., Mitchell, L., … Cutshall, N. S. (2011). N-Acylhydrazones as inhibitors of PDE10A. Bioorganic and Medicinal Chemistry Letters, 21(14), 4155–4159. https://doi.org/10.1016/j.bmcl.2011.05.100
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
Already have an account? Sign in
Sign up for free