The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death

  • Pedersen S
  • 4


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The ubiquitous plasma membrane Na+/H+ exchanger NHE1 is highly conserved across vertebrate species and is extensively characterized as a major membrane transport mechanism in the regulation of cellular pH and volume. In recent years, the understanding of the role of NHE1 in regulating cell function has expanded from one of a household protein involved in ion homeostasis to that of a multifaceted regulator and/or modulator of a wide variety of cell functions. NHE1 plays pivotal roles in response to a number of important physiological stress conditions which, in addition to cell shrinkage and acidification, include hypoxia and mechanical stimuli, such as cell stretch. It has recently become apparent that NHE1-mediated modulation of, e.g., cell migration, morphology, proliferation, and death results not only from NHE1-mediated changes in pHi, cell volume, and/or [Na+]i, but also from direct protein-protein interactions with, e.g., ezrin/radixin/moesin (ERM) proteins and regulation of cellular signaling events, including the activity of mitogen-activated protein kinases (MAPKs) and Akt/protein kinase B (PKB). The aim of this review is to present and discuss new findings implicating NHE1 activation as a central signaling event activated by stress conditions and modulating cell proliferation and death. The pathophysiological importance of NHE1 in modulating the balance between cell proliferation and cell death in cancer and in ischemia/severe hypoxia will also be briefly addressed

Author-supplied keywords

  • Animals
  • Anoxia
  • Biochemistry
  • Biology
  • Cell Death
  • Cell Proliferation
  • Cell Size
  • Erythrocytes
  • Homeostasis
  • Mitogen-Activated Protein Kinases
  • Molecular Biology
  • Neoplasms
  • Osmotic Pressure
  • PH
  • Phosphotransferases
  • Protein Kinases
  • Proteins
  • Research
  • Signal Transduction
  • Sodium-Hydrogen Antiporter
  • Stress
  • Stress,Physiological
  • physiology
  • physiopathology
  • review

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PMID: 16586098


  • S F Pedersen

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free