Nanodomain cubic cuprous oxide as reusable catalyst in one-pot synthesis of 3-alkyl/aryl-3-(pyrrole-2-yl/indole-3-yl)-2-phenyl-2,3-dihydro-isoindolinones in aqueous medium

  • Sarkar S
  • Chatterjee N
  • Roy M
 et al. 
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An environmentally benign one-pot protocol has been developed for the syntheses of 3-alkyl/aryl-3-(pyrrole/indole-2/3-yl)-2-phenyl-2,3-dihydro- isoindolinones via a multi-component one-pot reaction involving 2-iodo-N-phenylbenzamides, terminal alkyne and substituted indoles/pyrroles in aqueous medium using cubic cuprous oxide nanoparticles as catalyst. It involves domino Sonogashira-5-exo-dig-cyclization followed by regioselective nucleophilic addition of indoles or pyrroles, in aqueous medium without using any surfactants or additional ligands. © The Royal Society of Chemistry 2014.

Author-supplied keywords

  • Addition reactions
  • Catalysts
  • Environmentally benign
  • Multicomponents
  • One-pot protocol
  • One-pot reaction
  • One-pot synthesis
  • Potassium compounds
  • Regioselective nucleophilic addition
  • Reusable catalysts
  • Substituted indoles
  • Synthesis (chemical)

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  • S Sarkar

  • N Chatterjee

  • M Roy

  • R Pal

  • S Sarkar

  • A K Sen

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