Nasopharyngeal carriage of resistant pneumococci in young South Indian infants.

  • Coles C
  • Rahmathullah L
  • Kanungo R
 et al. 
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Abstract

Streptococcus pneumoniae is the leading bacterial cause of life-threatening infections in infants. Although antibiotic resistance affects management of pneumococcal infections, few data on patterns of resistance are available for India. We examined nasopharyngeal carriage of antibiotic-resistant pneumococci in 464 South Indian infants between 2 and 6 months. Newly acquired serotypes were screened for susceptibility to cotrimoxazole, erythromycin and penicillin using disk diffusion. Cumulative prevalence of pneumococcal carriage rose from 53.9% at 2 months to 70.2% at 6 months. The prevalence of strains that were not susceptible to penicillin, cotrimoxazole and erythromycin was 34, 81.1 and 37.2%, respectively. Carriage of erythromycin non-susceptible strains declined significantly between ages 4 months and 6 months (44.1 vs. 10.7%). More than 87% of the isolates screened were non-susceptible to > or = 1 antibiotic. Serogroups/types that were most frequently non-susceptible to 1 or more antibiotics were 6, 9, 14, 19 and 23. Less than 1% of the isolates were multi-drug resistant. Widespread use of antibiotics in South India has resulted in S. pneumoniae becoming non-susceptible to some commonly used antibiotics. Monitoring trends in antibiotic susceptibility and making antibiotics available only through prescription from a health care worker may slow the spread of resistant pneumococci and improve management of pneumococcal infections in South India.

Author-supplied keywords

  • Carrier State
  • Drug Resistance, Microbial
  • Female
  • Humans
  • India
  • Infant
  • Infant, Newborn
  • Male
  • Nasopharynx
  • Nasopharynx: microbiology
  • Physician's Practice Patterns
  • Pneumococcal Infections
  • Pneumococcal Infections: drug therapy
  • Pneumococcal Infections: epidemiology
  • Prevalence
  • Streptococcus pneumoniae
  • Streptococcus pneumoniae: pathogenicity

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Authors

  • C L Coles

  • L Rahmathullah

  • R Kanungo

  • R D Thulasiraj

  • J Katz

  • M Santosham

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