Natalizumab for the treatment of relapsing multiple sclerosis

  • Rudick R
  • Panzara M
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Abstract

Natalizumab is an alpha4-integrin antagonist approved as monotherapy for patients with relapsing multiple sclerosis (MS), based on demonstrated efficacy in the pivotal AFFIRM study (N = 942). Natalizumab monotherapy reduced risk of disability progression by 42%-54% and annualized relapse rate by 68% during a period of 2 years. Natalizumab was also associated with significant reductions in number of T2-hyperintense, gadolinium-enhancing, and T1-hypointense lesions and in volume of T2-hyperintense lesions (all p < 0.001) on magnetic resonance imaging. Furthermore, natalizumab-treated patients in AFFIRM experienced significant improvements from baseline in the physical and mental components of the Short Form-36 (p

Author-supplied keywords

  • ??4-integrin antagonist
  • Multiple sclerosis
  • Natalizumab

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Authors

  • Richard A. Rudick

  • Michael A. Panzara

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