Near infrared light triggered release of biomacromolecules from hydrogels loaded with upconversion nanoparticles

  • Yan B
  • Boyer J
  • Habault D
 et al. 
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Abstract

Using a photosensitive hybrid hydrogel loaded with upconversion nanoparticles (UCNPs), we show that continuous-wave near-infrared (NIR) light (980 nm) can be used to induce the gel-sol transition and release large, inactive biomacromolecules (protein and enzyme) entrapped in the hydrogel into aqueous solution "on demand", where their bioactivity is recovered. This study is a new demonstration and development in harnessing the unique multiphoton effect of UCNPs for photosensitive materials of biomedical interest.

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Authors

  • Bin Yan

  • John Christopher Boyer

  • Damien Habault

  • Neil R. Branda

  • Yue Zhao

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