Using a photosensitive hybrid hydrogel loaded with upconversion nanoparticles (UCNPs), we show that continuous-wave near-infrared (NIR) light (980 nm) can be used to induce the gel-sol transition and release large, inactive biomacromolecules (protein and enzyme) entrapped in the hydrogel into aqueous solution "on demand", where their bioactivity is recovered. This study is a new demonstration and development in harnessing the unique multiphoton effect of UCNPs for photosensitive materials of biomedical interest. © 2012 American Chemical Society.
CITATION STYLE
Yan, B., Boyer, J. C., Habault, D., Branda, N. R., & Zhao, Y. (2012). Near infrared light triggered release of biomacromolecules from hydrogels loaded with upconversion nanoparticles. Journal of the American Chemical Society, 134(40), 16558–16561. https://doi.org/10.1021/ja308876j
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