Negative feedback regulation and desensitization of insulin and epidermal growth factor stimulated p21ras activation

  • Langlois W
  • Sasaoka T
  • Saltiel A
 et al. 
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Abstract

Insulin and epidermal growth factor receptors trans-mit signals for cell proliferation and gene regulation through formation of active GTP-bound p21 ras mediated by the guanine nucleotide exchange factor Sos. Sos is constitutively bound to the adaptor protein Grb2 and growth factor stimulation induces association of the Grb2/Sos complex with Shc and movement of Sos to the plasma membrane location of p21 ras

Author-supplied keywords

  • Epidermal Growth Factor
  • FEEDBACK
  • GROWTH
  • Growth factor
  • Growth-factor
  • INSULIN
  • P21ras activation
  • activation
  • regulation

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Authors

  • W J Langlois

  • T Sasaoka

  • a R Saltiel

  • J M Olefsky

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