Neural differentiation from embryonic stem cells: which way?

  • Du Z
  • Zhang S
  • 38

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Embryonic stem (ES) cells can in theory produce all cell types of a living organism while renewing themselves with a stable genetic background. These unique features make ES cells a favorable tool for biomedical researches as well as a potential source for therapeutic application. A first step for approaching to ES cells is the directed differentiation to cells of interest, such as the neural cell lineage. Here, we summarize the up and down sides of each category of neural differentiation protocols that have so far been used in mouse and human ES cells, and introduce an efficient and plausible method used in our laboratory for derivation of neuroectodermal cells from human ES cells. This synthesis has led to our suggestions on issues for future design of neural differentiation protocols.

Author-supplied keywords

  • Animals
  • Cell Differentiation
  • Cell Division
  • Embryo
  • Fibroblast Growth Factor 2
  • Fibroblast Growth Factor 2: physiology
  • Humans
  • Mammalian
  • Nervous System
  • Nervous System: embryology
  • Neurons
  • Neurons: cytology
  • Signal Transduction
  • Stem Cells
  • Stem Cells: cytology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Zhong-Wei Du

  • Su-Chun Zhang

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free