Neural Probes for Concurrent Detection of Neurochemical and Electrophysiological Signals in vivo.

  • Johnson M
  • Franklin R
  • Scott K
 et al. 
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Abstract

Electrochemical sensing with microelectrode arrays provides a means for monitoring neurotransmitter dynamics across multiple locations within a micro-scale region of brain tissue. Here we present a multi-modal neural probe design for concurrent recording of neurochemical and electrophysiological signals in vivo. Prior to implantation, platinum sites on each array underwent platinum-black electroplating and Nafion electropolymerization, which increased sensitivity to dopamine by 74% and decreased sensitivity to common interferents by at least 89%. In a series of three rats, we applied various electrochemical waveforms to platinum sites and monitored neural activity on adjacent iridium sites. We found that chronoamperometry and constant-potential amperometry did not alter firing rates at +0.25, +0.50, and +0.75 V. In addition, we have demonstrated multi-modal recordings of striatal neurons in response to medial forebrain bundle stimulation.

Author-supplied keywords

  • 1
  • 16-channel multi-modal probe design
  • 177µm 2
  • 450µm 2
  • and platinum
  • chemical sensing
  • dopamine
  • electrode sites
  • fig
  • microelectrodes
  • neural probe
  • neural recordings
  • two 8000µm 2 sites
  • were
  • with alternating iridium

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Authors

  • M Johnson

  • R Franklin

  • K a Scott

  • R Brown

  • D Kipke

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