Neurocognitive features distinguishing primary central nervous system lymphoma from other possible causes of rapidly progressive dementia

  • M.B. D
  • M.F. M
  • Deutsch M
 et al. 
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Abstract

Objective: Define the neurocognitive features of primary central nervous system lymphoma (PCNSL) presenting with dementia, and compare with other causes of rapidly progressive dementia (RPD). Background: PCNSL can present as an RPD. Differentiating PCNSL from other RPDs is critical because lymphomatous dementia may be reversible, and untreated PCNSL is fatal. Methods: We performed a meta-analysis of case reports of dementia from PCNSL (between 1950 and 2013); 20 patients (14 with lymphomatosis cerebri) met our criteria. We compared these patients to a case series of patients with RPD from Creutzfeldt-Jakob disease and other non-PCNSL etiologies (Sala et al, 2012. Alzheimer Dis Assoc Disord. 26:267-271). Results: Median age was 66 years (range 41 to 81); 70% were men. Time from symptom onset to evaluation was

Author-supplied keywords

  • 80 and over
  • Adult
  • Aged
  • Apathy
  • Brain
  • Central Nervous System Diseases
  • Central Nervous System Neoplasms
  • Cognition
  • Creutzfeldt Jakob disease
  • Creutzfeldt-Jakob Syndrome
  • Dementia
  • Diagnosis
  • Differential
  • Disease Progression
  • Electroencephalography
  • Female
  • Gait
  • Humans
  • Lymphoma
  • Magnetic Resonance Imaging
  • Male
  • Memory Disorders
  • Middle Aged
  • Retrospective Studies
  • Speech Disorders
  • Time Factors
  • Tomography
  • X-Ray Computed
  • adult
  • aged
  • behavior change
  • brain atrophy
  • clinical article
  • cognitive defect
  • complications
  • dementia
  • diagnosis
  • etiology
  • female
  • headache
  • human
  • lymphomatosis
  • male
  • memory disorder
  • meta analysis
  • myoclonus
  • neurologic disease
  • parkinsonism
  • pathology
  • pleocytosis
  • primary central nervous system lymphoma
  • priority journal
  • protein cerebrospinal fluid level
  • psychology
  • rapidly progressive dementia
  • review
  • seizure
  • white matter

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Authors

  • Deutsch M.B.

  • Mendez M.F.

  • Mariel B Deutsch

  • Mario F Mendez

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