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Neurologic uses of botulinum neurotoxin type A

Ney J, Joseph K ...see all

Neuropsychiatric Disease and Treatment, vol. 3, issue 6 (2007) pp. 785-798

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Abstract

This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical trials (as appropriate), including facial movement disorders, focal neck and limb dystonias, spasticity, hypersecretory syndromes, and pain.

Author-supplied keywords

  • BOTOX??
  • Botulinum neurotoxins
  • Chemodenervation
  • Dysport??

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  • PUI: 351082754
  • ISSN: 11766328
  • PMID: 19300614
  • SCOPUS: 2-s2.0-38149008032
  • ISBN: 1176-6328
  • SGR: 38149008032

Authors

  • John P. Ney

  • Kevin R. Joseph

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