Neurologic uses of botulinum neurotoxin type A

Ney J, Joseph K ...see all

Neuropsychiatric Disease and Treatment, vol. 3, issue 6 (2007) pp. 785-798

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This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical trials (as appropriate), including facial movement disorders, focal neck and limb dystonias, spasticity, hypersecretory syndromes, and pain.

Author-supplied keywords

  • BOTOX??
  • Botulinum neurotoxins
  • Chemodenervation
  • Dysport??

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  • John P. Ney

  • Kevin R. Joseph

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