Neurophysiology of the neuromuscular junction: Overview

  • Ruff R
  • 43


    Mendeley users who have this article in their library.
  • 20


    Citations of this article.


This manuscript reviews the physiology of neuromuscular transmission with emphasis on four features: (1) the structure of the neuromuscular junction, (2) release of vesicles of acetylcholine from the nerve terminal, (3) the roles of postsynaptic Na(+) channels and acetylcholine receptors in converting the chemical signal from the nerve terminal into a propagated action potential on the muscle fiber, and (4) the safety factor for neuromuscular transmission. It also introduces new information about how the neuromuscular junction maintains physiological integrity during muscle fiber stretch and contraction.

Author-supplied keywords

  • Acetylcholine esterase
  • Contractility
  • Neuromuscular junction
  • Neuromuscular transmission
  • Quantal transmitter release
  • Safety factor
  • Skeletal muscle
  • Sodium channels
  • Transmitter release

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Robert L. Ruff

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free