This manuscript reviews the physiology of neuromuscular transmission with emphasis on four features: (1) the structure of the neuromuscular junction, (2) release of vesicles of acetylcholine from the nerve terminal, (3) the roles of postsynaptic Na+ channels and acetylcholine receptors in converting the chemical signal from the nerve terminal into a propagated action potential on the muscle fiber, and (4) the safety factor for neuromuscular transmission. It also introduces new information about how the neuromuscular junction maintains physiological integrity during muscle fiber stretch and contraction.
CITATION STYLE
Ruff, R. L. (2003). Neurophysiology of the neuromuscular junction: Overview. In Annals of the New York Academy of Sciences (Vol. 998, pp. 1–10). New York Academy of Sciences. https://doi.org/10.1196/annals.1254.002
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