Neuroplasticity and memory formation in major depressive disorder: An imaging genetics perspective on serotonin and BDNF

  • Kuhn M
  • Popovic A
  • Pezawas L
  • 98

    Readers

    Mendeley users who have this article in their library.
  • 14

    Citations

    Citations of this article.

Abstract

A vast number of imaging studies have demonstrated the impact of serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) on emotion and memory-related networks in the context of Major Depressive Disorder (MDD). Underlying molecular mechanisms that affect the functionality of these networks have been examined in detail in animals and corroborate imaging findings. The crucial role of 5-HT and BDNF signaling in the context of MDD is reflected in the etiologic models of MDD such as the monoamine or neuroplasticity hypothesis as well as in pharmacological models of antidepressant response. While antidepressant drug treatment has been primarily linked to the modulation of emotion-related networks, cognitive behavioral therapy has been implicated in a top-down control of limbic structures. Initially, a simple lack of monoamines or BDNF has been proposed as causal factor of MDD etiology. However, recent findings suggest a much more complex neurobiology emphasizing epistatic and epigenetic mechanisms responsible for structural and functional changes observed in emotion and memory-related brain regions of healthy subjects and MDD patients. In this review, which focuses on neuroimaging studies in the context of MDD, the authors will provide a comprehensive overview of these networks as well as on the specific role of 5-HT and BDNF in their development and function.

Author-supplied keywords

  • BDNF
  • Neuroimaging
  • SLC6A4
  • epistasis
  • functional magnetic resonance imaging
  • learning
  • major depressive disorder
  • memory
  • neuroplasticity
  • selective serotonin re-uptake inhibitor
  • serotonin transporter
  • tryptophan

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Manuel KuhnUniversity Hospital Hamburg Eppendorf Institute of Systems Neuroscience

    Follow
  • Ana Popovic

  • Lukas Pezawas

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free