Skip to content
Journal article

Neuroprotective effect of recombinant human erythropoietin on optic nerve injury in rats.

Wang H, Liu Z, Zhuang X, Wang M, Xu L ...see all

Chinese medical journal, vol. 122, issue 17 (2009) pp. 2008-2012

  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.
  • N/A

    Views

    ScienceDirect users who have downloaded this article.
Sign in to save reference

Abstract

Optic nerve injury, caused by retinal and optic nerve diseases, can eventually result in vision loss. To date, few effective treatments have been discovered to restore visual function. Previous studies showed that recombinant human erythropoietin (rhEPO) has a neuroprotective effect on the central nervous system, particularly in nerve injury. In this study, we investigated the effects of rhEPO on axonal regeneration and functional restoration following optic nerve injury. This was done by measuring the expression of growth associated protein 43 (GAP-43), a marker for neuronal regeneration, on the retina and flash-visual evoked potential (F-VEP).

Author-supplied keywords

  • Animals; Erythropoietin; Evoked Potentials
  • Visual; GAP-43 Protein; Humans; Immunohistochemis
  • Wistar; Recombinant Proteins; Retina

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Hui Wang

  • Zhe-li Liu

  • Xiao-tong Zhuang

  • Min-fang Wang

  • Li Xu

Cite this document

Choose a citation style from the tabs below