Neuropsychiatric symptoms in the prodromal stages of dementia

  • Stella F
  • Radanovic M
  • Balthazar M
 et al. 
  • 60


    Mendeley users who have this article in their library.
  • 12


    Citations of this article.


and Introduction Abstract Purpose of Review. To critically discuss the neuropsychiatric symptoms in the prodromal stages of dementia in order to improve the early clinical diagnosis of cognitive and functional deterioration. Recent Findings. Current criteria for cognitive syndrome, including Alzheimer's disease, comprise the neuropsychiatric symptoms in addition to cognitive and functional decline. Although there is growing evidence that neuropsychiatric symptoms may precede the prodromal stages of dementia, these manifestations have received less attention than traditional clinical hallmarks such as cognitive and functional deterioration. Depression, anxiety, apathy, irritability, agitation, sleep disorders, among other symptoms, have been hypothesized to represent a prodromal stage of dementia or, at least, they increase the risk for conversion from minor neurocognitive disorder to major neurocognitive disorder. Longitudinal investigations have provided increased evidence of progression to dementia in individuals with minor neurocognitive disorder when neuropsychiatric symptoms also were present. Summary. Although neuropsychiatric symptoms are strongly associated with a higher risk of cognitive and functional deterioration, frequently the clinician does not acknowledge these conditions as increasing the risk of dementia. When the clinician accurately diagnoses neuropsychiatric symptoms in the prodromal stage of dementia, he could early establish appropriate treatment and, may be, delay the beginning of clinical and functional deterioration.

Author-supplied keywords

  • Alzheimer's disease
  • mild behavior impairment
  • minor neurocognitive disorder
  • neuropsychiatric symptoms
  • prodromal dementia

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Florindo Stella

  • Márcia Radanovic

  • Márcio L F Balthazar

  • Paulo R. Canineu

  • Leonardo C. De Souza

  • Orestes V. Forlenza

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free