Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis.

  • Boudreau V
  • Yatham L
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OBJECTIVE: Although cognitive deficits are prominent in symptomatic patients with bipolar disorder, the extent and pattern of cognitive impairment in euthymic patients remain uncertain., METHOD: Neuropsychological studies comparing euthymic bipolar patients and healthy controls were evaluated. Across studies, effect sizes reflecting patient-control differences in task performance were computed for the 15 most frequently studied cognitive measures in the literature., RESULTS: Across the broad cognitive domains of attention/processing speed, episodic memory, and executive functioning, medium-to-large performance effect size differences were consistently observed between patients and controls, favoring the latter. Deficits were not observed on measures of vocabulary and premorbid IQ., CONCLUSION: Meta-analytic findings provide evidence of a trait-related neuropsychological deficit in bipolar disorder involving attention/processing speed, memory, and executive function. Findings are discussed with regard to potential moderators, etiologic considerations, limitations, and future directions in neuropsychological research on bipolar disorder.

Author-supplied keywords

  • *Bipolar Disorder/di [Diagnosis]
  • *Cognition Disorders/di [Diagnosis]
  • *Neuropsychological Tests
  • Affect
  • Attention
  • Bipolar Disorder/px [Psychology]
  • Cognition Disorders/px [Psychology]
  • Humans
  • Mental Recall
  • Problem Solving
  • Reaction Time

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  • V G Boudreau

  • L N Yatham

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