Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium.

  • Conlan J
  • North R
  • 25


    Mendeley users who have this article in their library.
  • 150


    Citations of this article.


The rate of growth of Listeria monocytogenes in the livers of mice infected intravenously with a lethal or sublethal inoculum of this facultative intracellular bacterium is greatly increased if neutrophils and other host cells are prevented from accumulating at foci of infection during the first 24 h by treatment with a monoclonal antibody (5C6) specific for the type 3 complement receptor of myelomonocytic cells. A histological examination of the livers of control mice showed that the accumulation of neutrophils at infectious foci resulted in the focal destruction of infected hepatocytes. In contrast, failure of neutrophils to accumulate at these sites in 5C6-treated mice allowed Listeria to multiply extensively in hepatocytes without destroying them. The results indicate that neutrophils play an important role in early defense against listeriosis in the liver by destroying infected hepatocytes, thereby reducing the opportunity for Listeria to multiply in permissive cells. In this way, neutrophils serve to break the chain of cell-to-cell spread of infection.

Author-supplied keywords

  • Animals
  • Antibodies, Monoclonal
  • Cytotoxicity, Immunologic
  • Female
  • Immunity, Cellular
  • Listeria monocytogenes
  • Listeria monocytogenes: immunology
  • Listeriosis
  • Listeriosis: immunology
  • Listeriosis: pathology
  • Liver
  • Liver: microbiology
  • Liver: pathology
  • Mice
  • Neutrophils
  • Neutrophils: immunology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • J W Conlan

  • R J North

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free