New adjacent bis-tetrahydrofuran annonaceous acetogenins from Annona muricata

  • Chang F
  • Liaw C
  • Lin C
 et al. 
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Bioactivity-guided fractionation led to the isolation of two new Annonaceous acetogenins, annocatacin A ( 1). and annocatacin B ( 2). from the seeds and the leaves, respectively, of Annona muricata. Compounds 1 and 2 are the first examples where the adjacent bis-tetrahydrofuran ring system is located at C-15. The new structures were elucidated and characterized by spectral and chemical methods. Both Annonaceous acetogenins 1 and 2 showed significant in vitro cytotoxicity toward the human hepatoma cell lines, Hep G2 and 2,2,15, and were compared with the known adjacent bis-tetrahydrofuran acetogenins, neoannonin ( 3). desacetyluvaricin ( 4). bullatacin ( 5). asimicin ( 6). annoglaucin ( 7). squamocin ( 8). and rollimusin ( 9).

Author-supplied keywords

  • Annocatacin A
  • Annocatacin B
  • Annona muricata
  • Annonaceae
  • Annonaceous acetogenins
  • Cytotoxic
  • Human hepatoma cell

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  • Fang Rong Chang

  • Chih Chuang Liaw

  • Chih Yuan Lin

  • Chi Jung Chou

  • Hui Fen Chiu

  • Yang Chang Wu

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