Bioactivity-guided fractionation led to the isolation of two new Annonaceous acetogenins, annocatacin A (1) and annocatacin B (2), from the seeds and the leaves, respectively, of Annona muricata. Compounds 1 and 2 are the first examples where the adjacent bis-tetrahydrofuran ring system is located at C-15. The new structures were elucidated and characterized by spectral and chemical methods. Both Annonaceous acetogenins 1 and 2 showed significant in vitro cytotoxicity toward the human hepatoma cell lines, Hep G2 and 2,2,15, and were compared with the known adjacent bis-tetrahydrofuran acetogenins, neoannonin (3), desacetyluvaricin (4), bullatacin (5), asimicin (6), annoglaucin (7), squamocin (8), and rollimusin (9).
CITATION STYLE
Chang, F. R., Liaw, C. C., Lin, C. Y., Chou, C. J., Chiu, H. F., & Wu, Y. C. (2003). New adjacent bis-tetrahydrofuran annonaceous acetogenins from Annona muricata. Planta Medica, 69(3), 241–246. https://doi.org/10.1055/s-2003-38485
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