New anticoagulant drugs for treatment of venous thromboembolism and stroke prevention in atrial fibrillation

  • Tripodi A
  • Palareti G
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Abstract

Venous thromboembolism (including deep vein thrombosis and pulmonary embolism) and atrial fibrillation are common conditions in Western countries. The mainstay of treatment and prevention for these diseases is fast-acting anticoagulant drugs such as heparins and vitamin K antagonists. The use of these drugs is, however, complex and demanding for both patients and physicians. Recently, new antithrombotic drugs that act directly by inhibiting activated coagulation factors such as factor X or thrombin have been developed and investigated in phase III clinical trials. The aim of this article is to review: (i) the need to develop new drugs; (ii) their efficacy/safety as demonstrated in clinical trials; (iii) the need for laboratory monitoring and (iv) the direction towards the use of these new drugs in the real-life clinical situation.

Author-supplied keywords

  • Anticoagulants/ therapeutic use
  • Atrial Fibrillation/ complications
  • Benzimidazoles/pharmacology/ therapeutic use
  • Clinical Trials as Topic
  • Clinical Trials, Phase III as Topic
  • Dabigatran
  • Drugs, Investigational
  • Heparin/therapeutic use
  • Humans
  • International Normalized Ratio
  • Morpholines/pharmacology/ therapeutic use
  • Pyrazoles/pharmacology/ therapeutic use
  • Pyridones/pharmacology/ therapeutic use
  • Rivaroxaban
  • Stroke/etiology/ prevention & control
  • Thiophenes/pharmacology/ therapeutic use
  • Treatment Outcome
  • Venous Thromboembolism/etiology/ prevention & cont
  • Vitamin K/antagonists & inhibitors
  • beta-Alanine/ analogs & derivatives/pharmacology/t

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Authors

  • A Tripodi

  • G Palareti

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